Articles on 3Rs topics

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Show all (18) Recording (4) Protocol (2) Report (7) Support (5)
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Show all (18) Refinement (3) Replacement (9) Animal Welfare Legislation (2) General aspects (4)
Support General aspects
The 3R-Concept
Deutsch
Run Time 04:30 min

The 3R-Concept

3R, definition, replace, reduce, refine

This article details what the 3Rs concept means, where it comes from and what the legal implementation of the concept looks like in Germany.

details (DE)
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3R centres
Deutsch
Run Time 00:00 min

3R centres

3R dentres, germany, EU

Through this link we present various 3Rs centres in Germany and the EU via two interactive maps. Take a look now and then, as the content is currently still under construction.

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Report Refinement
Haemocompatibility
Deutsch
Run Time 02:04 min

Haemocompatibility

haemocompatibility, species-specific, chandler loop system, in vitro

In this article, a test is presented for determining the blood tolerability of medical devices.

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Report Replacement
EN MoNLightBoNT-Assay
Deutsch
Run Time 01:08 min

EN MoNLightBoNT-Assay

in vitro, activity testing, botulinum-neurotoxins

The MoNLightBoNT assay is designed to be used in the long run as an alternative to the mouse lethality test for the activity testing of various products containing Botulinum neurotoxin (BoNT), such as Botox®.

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Sens in Vitro
Deutsch
Run Time 02:02 min

Sens in Vitro

sens in vitro, skin sensitization, in vitro

For the introduction of alternative methods LuSens, kDPRA and epiCS it is important to address the topic of skin sensitization first.

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Protocol Replacement
kDPRA
Deutsch
Run Time 12:26 min

kDPRA

kDPRA, OECD testguideline no. 442C, skin sensitization, in vitro

kDPRA is an extension of DPRA, which is already internationally recognized. With kDPRA it is possible not only to draw conclusions on skin-sensitizing potential, but also to determine the potency of the skin-sensitizing effect.

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Protocol Replacement
LuSens
Deutsch
Run Time 01:03 min

LuSens

LuSens, OECD testguideline no. 442D, skin sensitisation, in vitro

The LuSens assay is an accepted alternative method for establishing whether a substance can trigger skin allergies. This article includes the experimental procedure of the cell-based LuSens assay.

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FAQs
Deutsch
Run Time 00:00 min

FAQs

FAQs, frequently asked, questions and answers

What do the 3Rs stand for? What is Replacement, Reduction, Refinement? What does the ordinance on the welfare of laboratory animals say and who were Russell & Burch? Frequently asked questions are answered here.

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Report Replacement
epiCS
Deutsch
Run Time 00:48 min

epiCS

replacement, skin modelling, in vitro, cells

The 3D cell model is produced from human Keratinocytes and used for studying the skin-damaging effect of substances. 

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