Articles on 3Rs topics
The 3R-Concept
3R, definition, replace, reduce, refineThis article details what the 3Rs concept means, where it comes from and what the legal implementation of the concept looks like in Germany.
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3R centres
3R dentres, germany, EUThrough this link we present various 3Rs centres in Germany and the EU via two interactive maps. Take a look now and then, as the content is currently still under construction.
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Haemocompatibility
haemocompatibility, species-specific, chandler loop system, in vitroIn this article, a test is presented for determining the blood tolerability of medical devices.
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EN MoNLightBoNT-Assay
in vitro, activity testing, botulinum-neurotoxinsThe MoNLightBoNT assay is designed to be used in the long run as an alternative to the mouse lethality test for the activity testing of various products containing Botulinum neurotoxin (BoNT), such as Botox®.
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Sens in Vitro
sens in vitro, skin sensitization, in vitroFor the introduction of alternative methods LuSens, kDPRA and epiCS it is important to address the topic of skin sensitization first.
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kDPRA
kDPRA, OECD testguideline no. 442C, skin sensitization, in vitrokDPRA is an extension of DPRA, which is already internationally recognized. With kDPRA it is possible not only to draw conclusions on skin-sensitizing potential, but also to determine the potency of the skin-sensitizing effect.
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LuSens
LuSens, OECD testguideline no. 442D, skin sensitisation, in vitroThe LuSens assay is an accepted alternative method for establishing whether a substance can trigger skin allergies. This article includes the experimental procedure of the cell-based LuSens assay.
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FAQs
FAQs, frequently asked, questions and answersWhat do the 3Rs stand for? What is Replacement, Reduction, Refinement? What does the ordinance on the welfare of laboratory animals say and who were Russell & Burch? Frequently asked questions are answered here.
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epiCS
replacement, skin modelling, in vitro, cellsThe 3D cell model is produced from human Keratinocytes and used for studying the skin-damaging effect of substances.
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