Articles on 3Rs topics

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Show all (20) Recording (4) Protocol (2) Report (7) Support (7)
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Show all (20) Refinement (4) Replacement (9) Animal Welfare Legislation (2) General aspects (5)
Support Refinement
Careful breeding planning in mice
Englisch
Run Time 1:03:41 min

Careful breeding planning in mice

This presentation by Prof. Kurt Reifenberg is a recommendation describing appropriate tools for careful breeding planning in mice and applying these tools to specific breedings.

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Support General aspects
The 3R-Concept
Deutsch
Run Time 04:30 min

The 3R-Concept

3R, definition, replace, reduce, refine

This article details what the 3Rs concept means, where it comes from and what the legal implementation of the concept looks like in Germany.

details (DE)
Support General aspects
3R centres in Germany
Deutsch
Run Time 00:00 min

3R centres in Germany

Through this link we present various 3R centres in Germany on an interactive map. Take a look now and then, as the content is currently still under construction.

details (DE)
Support General aspects
3R centres in Europe
Englisch
Run Time 00:00 min

3R centres in Europe

Through this link we present various 3R centres in Europe on an interactive map. Take a look now and then, as the content is currently still under construction.

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Report Refinement
Haemocompatibility
Deutsch
Run Time 02:04 min

Haemocompatibility

haemocompatibility, species-specific, chandler loop system, in vitro

In this article, a test is presented for determining the blood tolerability of medical devices.

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Report Replacement
MoNLightBoNT-Assay
Deutsch
Run Time 01:08 min

MoNLightBoNT-Assay

in vitro, activity testing, botulinum-neurotoxins

The MoNLightBoNT assay is designed to be used in the long run as an alternative to the mouse lethality test for the activity testing of various products containing Botulinum neurotoxin (BoNT), such as Botox®.

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Report Replacement
Sens in Vitro
Deutsch
Run Time 02:02 min

Sens in Vitro

sens in vitro, skin sensitization, in vitro

For the introduction of alternative methods LuSens, kDPRA and epiCS it is important to address the topic of skin sensitization first.

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Protocol Replacement
kDPRA
Deutsch
Run Time 12:26 min

kDPRA

kDPRA, OECD testguideline no. 442C, skin sensitization, in vitro

kDPRA is an extension of DPRA, which is already internationally recognized. With kDPRA it is possible not only to draw conclusions on skin-sensitizing potential, but also to determine the potency of the skin-sensitizing effect.

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Protocol Replacement
LuSens
Deutsch
Run Time 01:03 min

LuSens

LuSens, OECD testguideline no. 442D, skin sensitisation, in vitro

The LuSens assay is an accepted alternative method for establishing whether a substance can trigger skin allergies. This article includes the experimental procedure of the cell-based LuSens assay.

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